the ctla4 -819 c/t dimorphism is associated with type 1 diabetes in egyptian children
نویسندگان
چکیده
background : we investigated whether the c-819t snp of the ctla4 gene is associated with type 1 diabetes (t1d) for the egyptian population, a multi-ethnic group. we determined if expression of the c-819t snp correlated with onset of t1d for egyptian children and the prevalence of this polymorphism with respect to gender. methods: the association of the c-819t snp in intron 1 of the ctla-4 gene with t1d was investigated in 396 egyptian patients ≤ 14 years old and 396 control subjects >24 years old, with a similar ratio of males to females in both groups. the diagnosis of t1d was made based on ketoacidosis or ketosis with severe symptoms of acute onset at presentation and continuous dependence on insulin. controls were negative for anti-gad antibodies and were greater than 24 years of age. genotyping was performed using single strand conformation polymorphism (sscp), temperature gradient gel electrophoresis (tgge), polymerase chain reaction-restriction fragment length polymorphism (pcr-rflp), and reverse dot blot (rdb). results: the results demonstrated an association of the c-819t snp in the ctla-4 gene with t1d patients ( p = 0.0096). this association was more pronounced in children ≤5 years of age ( p = 0.0178) than in children 6-14 years of age ( p = 0.0437). moreover, this association was stratified by gender and age to female patients with age at onset 0-5 years old ( p = 0.0186) more than male patient with the age at onset 0-5 years old ( p = 0.3120). conclusion: the results support an association of the c-819t snp in the ctla-4 gene with egyptian children, specifically, females of onset age 0-5 years old.
منابع مشابه
prevalence of atopic dermatitis in children with type 1 diabetes mellitus in southeastern of iran (kerman province): a case-control study
چکیده ندارد.
15 صفحه اولVitamin D Deficiency is Associated with the Metabolic Syndrome in Subjects with Type 2 Diabetes
Background and Objectives: There is convincing evidence that subjects concomitantly affected by type 2 diabetes (T2D) and metabolic syndrome (MeS) are at greater risk for cardiovascular disease (CVD). Many metabolic derangements in T2D might be attributed to poor vitamin D status. The purpose of this study was to investigate the associations among vitamin D status, MeS and glycemic status in su...
متن کاملIs type 1 diabetes mellitus associated with ABO & Rh blood groups? A cross-sectional study
Background: This study was conducted to determine whether type 1 diabetes mellitus (T1DM) is associated with ABO & Rhesus (Rh) blood groups. Materials and Methods: This analytical cross sectional study was carried out on 77 patients suffering from T1DM and 96 healthy children less than 18 years old referring to Yazd Diabetes Research Center from April 2018 to May 2019. The ABO blood group and ...
متن کاملThe CTLA4 +49 A/G polymorphism is not associated with susceptibility to type 1 diabetes mellitus in the Portuguese population.
CTLA4 genetic polymorphisms have been associated with type 1 diabetes. We genotyped 207 patients and 249 controls for the most frequently investigated polymorphism of the CTLA4 gene (+49A/G (rs231775)). No significant differences were observed, suggesting that this polymorphism is not strongly associated with type 1 diabetes in the Portuguese population.
متن کاملInterferon- Gamma- Inducible Guanosine Triphosphate Cyclohydrolase 1 (GTP-CH1) Pathway Is Associated with Frailty in Egyptian Elderly
Background: Chronic low-grade inflammation may be a cardinal pathophysiologic feature in the pathogenesis of frailty. Interferon-gamma (INF-γ) is an understudied proinflammatory cytokine in frailty that induces many inflammatory pathways including the guanosine triphosphate cyclohydrolase 1 (GTP-CH1) pathway. Our aim was to evaluate the GTP-CH1 pathway in Egyptian frail elderly subjects. ...
متن کاملمنابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
iranian journal of public healthجلد ۳۸، شماره ۴، صفحات ۵۶-۶۳
میزبانی شده توسط پلتفرم ابری doprax.com
copyright © 2015-2023